“For example, have you thought about epigenetic effects that might be environmentally induced and can be transmitted across multiple subsequent generations? Genotypes of individuals in previous generations might even be a better predictor of phenotype than an individual’s own genotype.”
“I know that Copy-Number Polymorphic (CNP) duplications are highly variable among individual and are considered inaccessible by most existing genotyping and sequencing technologies, but I’m still getting my genome sequenced anyway.”
“Can you please help Eric understand that rare variants and large variants (deletions, duplications and inversions) are individually rare, but collectively common in the human population might account for much more of heritability than common variation. Nothing is known about these rare variants!”
–real science here.