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Archive for the ‘CNTNAP2’ Category

A look inside brains that carry (my) genetic risk for autism

Posted in Cerebellum, CNTNAP2, Frontal cortex, Frontal pole, Fusiform gyrus, Rostral fronto-occipital fasciculus, Thalamus, White matter, tagged , , , , , , , , , , , , , , , , , on March 5, 2010 | Leave a Comment »

Image via Wikipedia The A-to-T SNP rs7794745 in the CNTNAP2 gene was found to be associated with increased risk of autism (see Arking et al., 2008).  Specifically, the TT genotype, found in about 15% of individuals, increases these folks’ risk by about 1.2-1.7-fold.  Sure enough, when I checked my 23andMe profile, I found that I’m [...]

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“sintinaptoo” is a nonword that makes it hard to read nonwords

Posted in CNTNAP2, FOXP2, Myelin, Superior temporal cortex, tagged , , , , on November 7, 2008 | Leave a Comment »

Image by lintmachine via Flickr Like “Joe the Plumber” (whose real name is Samuel), CNTNAP2 (whose real name is CASPR2) has achieved a bit of fame lately.  While recently appearing almost everywhere (here, here, here) except FOX News, CNTNAP2 (not Joe the Plumber) is apparently a transcriptional target of the infamous FOXP2 “language gene” – [...]

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Autism risk factor CNTNAP2 bears phylogenetic evidence of positive selection

Posted in CNTNAP2, tagged , on March 7, 2008 | 1 Comment »

Image via Wikipedia I was just browsing the recent paper “Natural selection has driven population differentiation in modern humans” by Barreiro and colleagues (doi:10.1038/ng.78) and noticed in their supplementary table that the autism risk factor CNTNAP2 (as blogged about earlier here) contains at least one non-synonymous or 5′-UTR SNP with a high Fst value. Yann [...]

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Genes for language development and autism are expressed right where they should be

Posted in CNTNAP2, LDB1, Superior temporal cortex, tagged , , on December 7, 2007 | 1 Comment »

Image by pfv. via Flickr The acquisition of language in humans remains a complex and fascinating mystery from both a neuro- and evolutionary-biological perspective. Attempts to identify genetic regulators of neural processes that are involved in language acquisition have the potential to shed light, not only on the natural history of homo sapiens, but also, [...]

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