Check out the Interpretome! developed by students and staff at Stanford University. – I have 17 European alleles and 3 East Asian alleles … the genetic proof is in … white boys can’t jump. – I have 17 out of 32 Type 2 Diabetes risk alleles … put down those carbs now … and 19 [...]
Posts Tagged ‘23andMe’
Students implement the -ome of -omes
Posted in Uncategorized, tagged 23andMe, evolution, Personalized medicine on December 20, 2011 | Leave a Comment »
Parkinson’s hands that wobble like a newly evolved G:U base-pair
Posted in Dopamine, FGF20, Hippocampus, microRNA, tagged 23andMe, aging, Dopamine, Parkinson's disease on May 23, 2011 | Leave a Comment »
Hands shake and wobble as the decades pass … moreso in some. A recently evolved “T” allele (rs12720208) in the 3′ untranslated region (3′ UTR) of the FGF20 gene has been implicated in the risk of Parkinson’s Disease … namely by creating a wobbly G:U base-pair between microRNA-433 (miR-433) and the FGF20 transcript. Since the normal function [...]
That 70s personal genome
Posted in Chromosome structural variants, tagged 23andMe, Epigenetics, Genetic testing, Heritability, Personalized medicine on February 3, 2011 | 1 Comment »
“Listen Eric, you should think about how useful your newfangled Personal Genome is going to be. There are a lot of reasons why all this information doesn’t tell you much” “For example, have you thought about epigenetic effects that might be environmentally induced and can be transmitted across multiple subsequent generations? Genotypes of individuals in [...]
Photoperiod sensitive humans bloom much like spring flowers
Posted in Suprachiasmatic nucleus, tagged 23andMe, Add new tag, Biology, bipolardisorder, Brain, Circadian rhythm, CLOCK, Depression, DNA, Mental health, Mood disorder, Seasonal affective disorder on March 17, 2010 | Leave a Comment »
Image by noahg. via Flickr If you’ve started to notice the arrival of spring blossoms, you may have wondered, “how do the blossoms know when its spring?“ Well, it turns out that its not the temperature, but rather, that plants sense the length of the day-light cycle in order to synchronize their own life cycles [...]
rs2132683, rs713155 and white matter near the left posterior lateral ventricle emerge from 14 billion statistical tests (vGWAS)
Posted in Frontal cortex, Lateral ventricle, Temporal lobe, White matter, tagged 23andMe, Add new tag, Brain, brain structure, Development, Frontal lobe, Genetics, Genome-wide association study, GWAS, Neuroimaging, Statistical hypothesis testing, Statistics, Temporal lobe, White matter on March 12, 2010 | 1 Comment »
An historic find has occurred in the quest (gold-rush, if you will) to link genome variation with brain structure-function variation. This is the publication of the very first genome-wide (GWAS) analysis of individual voxels (voxels are akin to pixels in a photograph, but are rather 3D cubes of brain-image-space about 1mm on each side) of [...]
rs35753505 C-alleles make de l’Art Brut of the brain
Posted in Fusiform gyrus, Middle frontal gyrus, middle occipital gyrus, NRG1, tagged 23andMe, Add new tag, Art, Brain, Cognition, DNA, Frontal lobe, Functional magnetic resonance imaging, Fusiform gyrus, Memory, Mental disorder, Mental health, Outsider art, Painting on March 10, 2010 | Leave a Comment »
According to wikipedia, “Jean Philippe Arthur Dubuffet (July 31, 1901 – May 12, 1985) was one of the most famous French painters and sculptors of the second half of the 20th century.” “He coined the term Art Brut (meaning “raw art,” often times referred to as ‘outsider art’) for art produced by non-professionals working outside [...]
A look inside brains that carry (my) genetic risk for autism
Posted in Cerebellum, CNTNAP2, Frontal cortex, Frontal pole, Fusiform gyrus, Rostral fronto-occipital fasciculus, Thalamus, White matter, tagged 23andMe, Add new tag, autism, Autism spectrum, Brain, Development, Frontal lobe, Functional magnetic resonance imaging, Genetic testing, Genetics, Grey matter, Health, Mental disorder, Mental health, Neural development, Neurodevelopmental, synaptogenesis, White matter on March 5, 2010 | Leave a Comment »
Image via Wikipedia The A-to-T SNP rs7794745 in the CNTNAP2 gene was found to be associated with increased risk of autism (see Arking et al., 2008). Specifically, the TT genotype, found in about 15% of individuals, increases these folks’ risk by about 1.2-1.7-fold. Sure enough, when I checked my 23andMe profile, I found that I’m [...]
Genetic road signs for super-size coffee SUV drivers
Posted in ADORA2A, DRD2, Uncategorized, tagged 23andMe, Anxiety, Brain, Caffeine, Coffee, Cognition, Disorders, DNA, evolution, Genetic testing, Genetics, Mental disorder, Mental health, panic disorder, Personalized medicine, Psychoactive drug, Starbucks, Stress on March 4, 2010 | Leave a Comment »
If you’re a coffee drinker, you may have noticed the new super-sized portions available at Starbucks. On this note, it may be worth noting that caffeine is a potent psychoactive substance of which – too much – can turn your buzz into a full-blown panic disorder. The Diagnostic and Statistical Manual for psychiatry outlines a [...]
SLC1A1 SNPs as tiny deliveries on payment of big promise
Posted in SLC1A1, tagged 23andMe, anti-psychotic, Biology, clozapine, DNA, economics, genetic association, Genetic testing, Glutamate, Health care, medication, Mental disorder, Mental health, obsessive-compulsive, Personalized medicine, side-effect on December 15, 2009 | Leave a Comment »
Image via Wikipedia In their forecast “The World in 2010” special issue, the Economist points to “The looming crisis in human genetics” wherein scientists will reluctantly acknowledge that, even with super-cheap genome sequencing tools, we may not soon understand how genetic variation contributes to complex illness. The argument is a valid one to be sure, [...]
Indulging my inner rat over a few drinks
Posted in ADH1C, Amygdala, Caudate nucleus, CDH13, GATA4, Striatum, tagged 23andMe, Addiction, Alcohol, Alcoholism, Biology, Brain, Gene expression, Genetic testing, Genetics, Genome-wide association study, GWAS, Mental disorder, Mental health, Personalized medicine on November 16, 2009 | Leave a Comment »
Image by Scrunchleface via Flickr A recent GWAS study identified the 3′ region of the liver- (not brain) expressed PECR gene (rs7590720(G) and rs1344694(T)) on chromosome 2 as a risk factor for alcohol dependency. These results, as reported by Treutlein et al., in “Genome-wide Association Study of Alcohol Dependence” were based on a population of [...]
Catecholaminergic genes may help my son hear things more clearly
Posted in ADRA2A, Frontal cortex, Noradrenaline, Parietal cortex, TH, tagged 23andMe, Brain, Dopamine, Electroencephalography, ERP, Frontal lobe, Genetic testing, ICA, Independent Component Analysis, Literacy, Noradrenaline, Perception, Psychology, Reading, Signal transduction, Single-nucleotide polymorphism on October 9, 2009 | Leave a Comment »
This year, my 5 year-old son and I have passed many afternoons sitting on the living room rug learning to read. While he ever so gradually learns to decode words, eg. “C-A-T” sound by sound, letter by letter – I can’t help but marvel at the human brain and wonder what is going on inside. [...]
rs6265 moderates my hippocampus’ response to stress
Posted in BDNF, tagged 23andMe, BDNF, Brain-derived neurotrophic factor, Hippocampus, Major depressive disorder, Mental health, Stem cell, Stress on September 17, 2009 | 1 Comment »
Image by digitalART2 via Flickr In Robert Sapolsky’s book, “Why Zebras Don’t Get Ulcers“, he details a biological feedback system wherein psychological stress leads to the release of glucocorticoids that have beneficial effects in the near-term but negative effects (e.g. ulcers, depression, etc.) in the long-term. The key to getting the near-term benefits and avoiding [...]
Timing is everything – K+ channel bears the evidence across milliseconds and millenia
Posted in KCNH2, tagged 23andMe, Action potential, Dorsolateral prefrontal cortex, Frontal lobe, Gene, Gene expression, Hippocampus, Neuron, schizophrenia, Single-nucleotide polymorphism on August 22, 2009 | Leave a Comment »
**PODCAST accompanies this post** In the brain, as in other aspects of life, timing is everything. On an intuitive level, its pretty clear, that, since neurons have to work together in widely distributed networks, they have a lot of incentive to talk to each other in a rhythmic, organized way. Think of a choir that [...]
echoblog: Freakonomics hosts Anne Wojcicki
Posted in Uncategorized, tagged 23andMe, Genetic testing, Personalized medicine on August 12, 2009 | Leave a Comment »
Image via CrunchBase pointer to: Great Q&A on Freakonomics with 23andMe founder Anne Wojcicki. Nice overview of peoples’ concerns and interests in personal genomes.
Health management blogger shares personal genome experience
Posted in Uncategorized, tagged 23andMe, Genetic testing on July 30, 2009 | Leave a Comment »
pointer to Jen S. McCabe’s blog on healthcare management and gracious video share of her experience with her 23andMe personal genome data.
From the insula, rs4606 pulls a common thread back through developmental space and time
Posted in Amygdala, Insula, RGS2, tagged 23andMe, Anxiety, Development on July 7, 2009 | 1 Comment »
Image by freeparking via Flickr Back in the day, when the fam would get together at my parents’ house, I would enjoy shuffling through their box of old photos. Looking at childhood pictures of myself and relatives, it was natural to compare our adult selves to the old pictures and look for similarities – emotional [...]
Genetic risk expressed in early regulator of gene expression
Posted in NEUROG1, tagged 23andMe, Mental disorder, schizophrenia on June 29, 2009 | Leave a Comment »
Image via Wikipedia The basic helix-loop-helix transcription factor, neurogenin-1 is known to regulate neural development and neurite outgrowth. As such, it makes for a particularly interesting point to begin to understand mental illness and its complex developmental origins. The recent paper by Ho et al., “Basic helix–loop–helix transcription factor NEUROG1 and schizophrenia: Effects on illness [...]
Fun with Promethease: Ballparking my children’s genetic future in 214 seconds
Posted in Uncategorized, tagged 23andMe, Genetic testing on May 24, 2009 | 1 Comment »
Image via Wikipedia Just having some fun with SNPedia’s new release of Promethase (0.1.66) which now has a superfast analysis option ($2 via a link to your Amazon.com account) as well as the usual free regular speed option. I had some fun comparing my 23andMe profile to my wife’s using the experimental “breeding” tool and [...]
rs4570625 GG makes me a believer
Posted in Cingulate cortex, TPH2, tagged 23andMe, placebo on December 6, 2008 | Leave a Comment »
Image by `michelleBlack via Flickr “There is a sucker born every minute”, were the words that looped through my mind on the long train ride home after losing $200 in an unfortunate encounter with a card shark over on Canal Street, many years ago. I recall that when the card shark (actually a kindly old [...]
rs1815739 T/T kids dropped from sports programs everywhere – no chance for Olympic glory
Posted in Actin, ACTN3, tagged 23andMe on November 30, 2008 | 2 Comments »
Image by sean dreilinger via Flickr I was irked to see, in today’s New York Times, a picture of a young child having his cheek swabbed so that his parents could ascertain his status at the rs1815739 C/T variant . T-alleles at this site give rise to a premature stop codon in the alpha 3 [...]
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