Posts Tagged ‘23andMe’
Check out the Interpretome! developed by students and staff at Stanford University.
– I have 17 European alleles and 3 East Asian alleles … the genetic proof is in … white boys can’t jump.
– I have 17 out of 32 Type 2 Diabetes risk alleles … put down those carbs now … and 19 out of 30 Coronary Artery Disease risk alleles … and go for a jog.
– I have a combined Risk of Narcolepsy: 2.92 … but the score jumps to 85 with an issue of GENETICS in my hand.
– I’m not exactly on the leading edge of human evolution … a 72/110 of positive selection score.
– I’d better start saving for a long-ass retirement … probability of extreme longevity: 78.2
Hands shake and wobble as the decades pass … moreso in some.
A recently evolved “T” allele (rs12720208) in the 3′ untranslated region (3′ UTR) of the FGF20 gene has been implicated in the risk of Parkinson’s Disease … namely by creating a wobbly G:U base-pair between microRNA-433 (miR-433) and the FGF20 transcript. Since the normal function of microRNA-433 is to repress translation of proteins (such as FGF20), it is suspected that the PD risk “T” allele carriers make relatively more FGF20 … which, in turn … leads to the production of higher levels of alpha-synuclein (the main component of Lewy body fibrils, a pathological marker of diseases such as PD). This newly evolved T-allele has also been associated with brain structural differences in healthy individuals.
My hands will shake and wobble as the decades pass … but not because I carry the G:U wobble pairing between miR-433:FGF20. My 23andMe profile shows that I carry 2 C alleles and will produce the thermodynamically favorable G:C pairing. Something to keep in mind as I lose my mind in the decades to come.
“For example, have you thought about epigenetic effects that might be environmentally induced and can be transmitted across multiple subsequent generations? Genotypes of individuals in previous generations might even be a better predictor of phenotype than an individual’s own genotype.”
“I know that Copy-Number Polymorphic (CNP) duplications are highly variable among individual and are considered inaccessible by most existing genotyping and sequencing technologies, but I’m still getting my genome sequenced anyway.”
“Can you please help Eric understand that rare variants and large variants (deletions, duplications and inversions) are individually rare, but collectively common in the human population might account for much more of heritability than common variation. Nothing is known about these rare variants!”
–real science here.