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Posts Tagged ‘medication’

SLC1A1 SNPs as tiny deliveries on payment of big promise

Posted in SLC1A1, tagged , , , , , , , , , , , , , , , on December 15, 2009 | Leave a Comment »

Image via Wikipedia In their forecast “The World in 2010” special issue, the Economist points to “The looming crisis in human genetics” wherein scientists will reluctantly acknowledge that, even with super-cheap genome sequencing tools, we may not soon understand how genetic variation contributes to complex illness.  The argument is a valid one to be sure, [...]

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Noradrenergic relief of problematic impulses can be seen through the slit(rk1)

Posted in ADRA2A, Locus coeruleus, Noradrenaline, SLITRK1, tagged , , , , , on January 9, 2009 | Leave a Comment »

Image via Wikipedia A recent report by Katayama and colleagues [doi 10.1038/mp.2008.97] shows that the the gene slitrk1 – a known risk factor for the developmental disorders  Tourette’s syndrome and trichotillomania gives rise to increased levels of noradrenaline when the gene is inactivated in a developing mouse model.  In the U. S., the most frequently [...]

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Nothing is so much to be feared as the proton sensor ASIC1a

Posted in Amygdala, ASIC1a, Cingulate cortex, Glutamate, Stria terminalis, tagged , , on December 14, 2007 | Leave a Comment »

Image via Wikipedia Many of the unpleasant feelings and physiological changes associated with fear and anxiety can be traced back to a tiny brain region known as the amygdala. Neuroimaging studies often find this region abnormally active in people having difficulty down-regulating negative emotions. It is no surprise then, that when genes that regulate innate [...]

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Genes influence behavior via neural circuits – dude !

Posted in CB1 receptor, GABA, Glutamate, tagged , , on October 21, 2007 | Leave a Comment »

Image by Getty Images via Daylife Psychiatrists and families that cope with mental illness have long been aware of far reaching familial risk. Although the new genomics greatly accelerates the identification of specific risk alleles; the direct functional and mechanistic connections between these tiny bits of nucleic acid and large-scale changes in neural activity and [...]

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Ancient Greeks bear gifts rejecting the “my genes made me do it” defense

Posted in Uncategorized, tagged , , , , on August 28, 2007 | Leave a Comment »

Image by onecle via Flickr I much enjoyed the June 15th podcast “Blame it on my genes” hosted at the New York Academy of Sciences. Here, Professor Paul Appelbaum lays out a biological framework for behavioral genetics wherein genes influence an individual’s sensitivity to experience in ways that predispose or insulate them from illness. As [...]

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