Image via Wikipedia In their forecast “The World in 2010” special issue, the Economist points to “The looming crisis in human genetics” wherein scientists will reluctantly acknowledge that, even with super-cheap genome sequencing tools, we may not soon understand how genetic variation contributes to complex illness. The argument is a valid one to be sure, [...]
Posts Tagged ‘Mental health’
SLC1A1 SNPs as tiny deliveries on payment of big promise
Posted in SLC1A1, tagged 23andMe, anti-psychotic, Biology, clozapine, DNA, economics, genetic association, Genetic testing, Glutamate, Health care, medication, Mental disorder, Mental health, obsessive-compulsive, Personalized medicine, side-effect on December 15, 2009 | Leave a Comment »
Reciprocal genetics of autism vs. schizophrenia
Posted in Chromosome structural variants, Intronic or repetitive sequences, tagged autism, Autism spectrum, Cognition, Genetic testing, Mental disorder, Mental health, Neural development, Neurodevelopmental, schizophrenia on December 7, 2009 | 1 Comment »
The recent paper, “Comparative genomics of autism and schizophrenia” by Bernard Crespi and colleagues provides a very exciting take on how genetic data can be mined to understand cognitive development and mental illness. Looking at genetic association data for autism and schizophrenia, the authors point out that 4 loci are associated with both schizophrenia and [...]
Genes for Down syndrome isolated in mouse model
Posted in DYRK1A, KCNJ6, tagged Chromosome, Development, Down syndrome, Genetics, Hippocampus, Karyotype, Mental disorder, Mental health, mouse-model, Neurological Disorders, Prenatal, synaptogenesis, Trisomy 21 on December 2, 2009 | Leave a Comment »
The human brain is renown for its complexity. Indeed, while we often marvel at the mature brain in its splendid form and capability, its even more staggering to consider how to build such a powerful computing machine. Admittedly, mother nature has been working on this for a long time – perhaps since the first neuronal [...]
Video library of mental illness
Posted in Uncategorized, tagged Depression, Major depressive disorder, Mental disorder, Mental health, Psychology, schizophrenia, symptoms, videos on November 30, 2009 | Leave a Comment »
Image via Wikipedia pointer to symptommedia.org – fantastic video resource of specific symptoms of mental illness. “The intention of these clips are to be used in the classroom setting as visual compliments to the written description of symptoms for psychological phenomena found in the DSM handbook.”
ASIC1a and the fear of drowning
Posted in Amygdala, ASIC1a, tagged Acid, Blood, Carbon dioxide, drowning, Emotion, fear, Gene expression, Ion channel, Mental health, PH on November 27, 2009 | Leave a Comment »
Image by Sbrimbillina via Flickr Here’s a gene whose relationship to mental function is very straightforward. If you hold your breath, your blood pH falls (more CO2 leads to more free H+ protons dissolved in your blood stream). You also may become anxious, or worse if you are forced to hold your breath. How does [...]
Indulging my inner rat over a few drinks
Posted in ADH1C, Amygdala, Caudate nucleus, CDH13, GATA4, Striatum, tagged 23andMe, Addiction, Alcohol, Alcoholism, Biology, Brain, Gene expression, Genetic testing, Genetics, Genome-wide association study, GWAS, Mental disorder, Mental health, Personalized medicine on November 16, 2009 | Leave a Comment »
Image by Scrunchleface via Flickr A recent GWAS study identified the 3′ region of the liver- (not brain) expressed PECR gene (rs7590720(G) and rs1344694(T)) on chromosome 2 as a risk factor for alcohol dependency. These results, as reported by Treutlein et al., in “Genome-wide Association Study of Alcohol Dependence” were based on a population of [...]
Genetic causes and non-genetic consequences of schizophrenia play out within 2mm of neocortex
Posted in Uncategorized, tagged Archives of General Psychiatry, Brain, cerebral cortex, Development, Frontal lobe, Genetics, Mental disorder, Mental health, neocortex, Neuron, schizophrenia, synapse, synaptogenesis on November 15, 2009 | Leave a Comment »
Image by Biking Nikon PDX via Flickr One of the difficult aspects of understanding mental illness, is separating the real causes of the illness from what might be secondary or tertiary consequences of having the illness. If you think about a car whose engine is not running normally, there may be many observable things going [...]
Know thy epigenome in fatal purpose of the Heart
Posted in Cerebellum, Frontal cortex, NTRK2, tagged Depression, Development, DNA methylation, Epigenetics, Frontal lobe, Gene expression, Mental disorder, Mental health, Suicide on November 11, 2009 | Leave a Comment »
Image by sludgegulper via Flickr Few events are as hard to understand as the loss of a loved one to suicide – a fatal confluence of factors that are oft scrutinized – but whose analysis can provide little comfort to family and friends. To me, one frightening and vexing aspect of what is known about [...]
Krill-sized genetic risk factors caught with fine NRG1 netting
Posted in NRG1, tagged Brain, Development, Genetic marker, Genetic testing, Genome-wide association study, Mental health, schizophrenia on November 10, 2009 | Leave a Comment »
Image via Wikipedia The neuregulin-1 (NRG1) gene is widely known as one of the most well-replicated genetic risk factors for schizophrenia. Converging evidence shows that it is associated with schizophrenia at the gene expression and mouse model levels which are consistent with its molecular functions in neural development. However, in several recent genome-wide association studies [...]
Development of autism vs. schizophrenia depends on a mere 600 kilobases of DNA on chromosome 16
Posted in Chromosome structural variants, tagged autism, Bipolar disorder, Brain, Development, DNA, Gene expression, Mental disorder, Mental health, Mood, schizophrenia on October 27, 2009 | 1 Comment »
Image via Wikipedia File this story under “the more you know, the more you don’t know” or simply under “WTF!“ The new paper, “Microduplications of 16p11.2 are associated with schizophrenia” [doi:10.1038/ng.474] reveals that a short stretch of DNA on chromosome 16p11.2 is – very rarely – duplicated and – more rarely – deleted. In an [...]
Interview with Dan Weinberger, M.D. on KCNH2 and schizophrenia
Posted in Uncategorized, tagged Development, evolution, Frontal lobe, Gene expression, Genetic testing, Mental health, Podcast, schizophrenia on October 27, 2009 | Leave a Comment »
Image by Oliver Lavery via Flickr Daniel R. Weinberger, M.D., Chief of the Clinical Brain Disorders Branch and Director of the Genes, Cognition and Psychosis Program, National Institute of Mental Health discusses the background, findings and general issues of genes and mental illness in this brief interview on his paper, “A primate-specific, brain isoform of [...]
Minds on the Edge
Posted in Uncategorized, tagged economics, healthcare policy, Mental disorder, Mental health, Public Broadcasting Service, Television program on October 10, 2009 | 1 Comment »
pointer to: amazing project on the complexities of managing mental illness in America today. Scientific progress makes for policy dilemma in an era of economic decline. Heartbreaking. From the website: MINDS ON THE EDGE: Facing Mental Illness is a multi-platform media project that explores severe mental illness in America. The centerpiece of the project is [...]
Interview with Dr. Christina Barr
Posted in Uncategorized, tagged Addiction, Depression, Development, Emotion, evolution, Genetics, Mental health, National Institutes of Health, Stress on October 6, 2009 | Leave a Comment »
Image via Wikipedia Many thanks to Dr. Christina S. Barr from the National Institutes of Health/National Institute on Alcohol Abuse and Alcoholism-Laboratory of Clinical and Translational Studies, National Institutes of Health Animal Center for taking the time to comment on her team’s recent publication, “Functional CRH variation increases stress-induced alcohol consumption in primates” [doi:10.1073/pnas.0902863106] which [...]
podcast: Rett Syndrome Research Trust
Posted in MECP2, tagged Development, economics, Epigenetics, Genetic Disorders, Genetic testing, Mental disorder, Mental health, Podcast, Rett Syndrome on October 1, 2009 | Leave a Comment »
It was a delight today to chat with Monica Coenraads, Executive Director of the Rett Syndrome Research Trust. The RSRT has teamed up with a deeply focused world-class team of research scientists to translate the fruits of basic research on Rett syndrome into viable cures. Whether you are a scientist, student or concerned family member, [...]
Too much yin and not enough yang in cortical networks of MeCP2 mutant mice
Posted in MECP2, tagged autism, Development, Epigenetics, Gene, Gene expression, Long-Term Potentiation, MECP2, Mental disorder, Mental health, Mental retardation, Neural network, Neuron, Rett Syndrome on September 30, 2009 | 1 Comment »
Image via Wikipedia In previous posts, we have explored some of the basic molecular (de-repression of chromatin structure) and cellular (excess synaptogenesis) consequences of mutations in the MeCP2 gene – a.k.a the gene whose loss of function gives rise to Rett syndrome. One of the more difficult aspects of understanding how a mutation in a [...]
echoblog: Lives left behind in the era of institutionalization
Posted in Uncategorized, tagged Art, Mental disorder, Mental health on September 24, 2009 | Leave a Comment »
Image by audioeric via Flickr pointer to: The Willard Suitcase Exhibit on the documentation of forgotten belongings – hundreds of suitcases of personal belongings – of former residents of Willard Psychiatric Center.
resourceblog: Understanding the molecular basis of cognitive and social impairment in the autism spectrum disorders
Posted in HDACs, MECP2, tagged autism, Autism spectrum, Development, DNA, DNA methylation, Epigenetics, Gene, Gene expression, HDAC, Mental disorder, Mental health, Mutation, Rett Syndrome on September 24, 2009 | Leave a Comment »
Image via Wikipedia The cognitive and emotional impairments in the autism spectrum disorders can be difficult for parents and siblings to understand and cope with. Here are some graphics and videos that might assist in understanding how genetic mutations and epigenetic modifications can lead to various forms of social withdrawl commonly observed in the autism [...]
echoblog: “survey says” folks for genetic testing
Posted in Uncategorized, tagged Genetic testing, Mental disorder, Mental health, Statistical survey on September 19, 2009 | Leave a Comment »
Image via Wikipedia pointer to: Razib Khan’s results (600+ respondents!) survey on genetic testing and psychiatric illness. Very informative!
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