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Posts Tagged ‘Neuron’

Timing is everything – K+ channel bears the evidence across milliseconds and millenia

Posted in KCNH2, tagged , , , , , , , , , on August 22, 2009 | Leave a Comment »

**PODCAST accompanies this post** In the brain, as in other aspects of life, timing is everything.  On an intuitive level, its pretty clear, that, since neurons have to work together in widely distributed networks, they have a lot of incentive to talk to each other in a rhythmic, organized way. Think of a choir that [...]

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They’ve got NERVE

Posted in Uncategorized, tagged , , on March 19, 2009 | Leave a Comment »

Just stumbled onto this great educational resource …. From an article that describes NERVE: We’ve Got NERVE: A Call to Arms for Neuroscience Education Kyle J. Frantz, Colleen D. McNerney and Nicholas C. Spitzer “Are we neuroscientists doing our part to help revive science education, to stimulate teachers’ ingenuity, and diversify the intellectual capital among [...]

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Dendritic branching a good thing ? sez6 sez it ain’t so

Posted in SEZ6, tagged , , , , , , , on January 7, 2009 | Leave a Comment »

Image via Wikipedia If you like gardening, the doldrums of winter can be dreary indeed. Although I’d never admit to it, my neighbors might swear to having seen me outside strangely (pathetically) counting the number of branches on my icicle-laden roses and rhododendrons.  In any case, I do admit to spending way too much time [...]

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PSD-95 holds your long term memories in place

Posted in PSD95, tagged , on August 12, 2008 | Leave a Comment »

Image by pchow98 via Flickr One of the cool things about the brain & one of the ways in which it differs markedly from our current computer systems is that cells and synapses are living dynamic entities that grow and sprout new connections in response to experience. Since the 1980′s studies using protein synthesis inhibitors [...]

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Foxa2 (+/-) trapped as first true model for Parkinson disease

Posted in Dopamine, FOXA2, tagged , , on December 28, 2007 | Leave a Comment »

Image by Thomas Hawk via Flickr Mouse models of complex neurological illness are a powerful means to dissect molecular pathways and treatment paradigms. Current mouse models for the tremors and movement difficulties seen in Parkinson disease include genes such as parkin, alpha-synuclein, LRRK2, PINK1 and DJ-1. These models however, do not show the motor control [...]

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‘How to’ guide for adult brain repair is written in genetic code

Posted in Olfactory bulb, tagged , on December 25, 2007 | Leave a Comment »

Image by koolkao via Flickr Damage to the human brain, ie. loss of cells due to programmed or non-programmed cell death is presently considered to be an irreversible fate. Many a skilled neurosurgeon can place new neurons or stem cells into damaged areas, but that does little good unless those cells are able to sprout [...]

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Nothing is so much to be feared as the proton sensor ASIC1a

Posted in Amygdala, ASIC1a, Cingulate cortex, Glutamate, Stria terminalis, tagged , , on December 14, 2007 | Leave a Comment »

Image via Wikipedia Many of the unpleasant feelings and physiological changes associated with fear and anxiety can be traced back to a tiny brain region known as the amygdala. Neuroimaging studies often find this region abnormally active in people having difficulty down-regulating negative emotions. It is no surprise then, that when genes that regulate innate [...]

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Epigenetic perk keeps neurons bright-eyed and bushy tailed

Posted in BAF53b, SWI/SNF, tagged , , on December 2, 2007 | Leave a Comment »

Image via Wikipedia There is rightly much ado over the recent stem cell breakthrough. Indeed, who wouldn’t want to have an eternal supply of sprightly new cells to swap in to replace run-down geezer cells. Swapping in a neuron, however, is not quite so simple, as these cells are highly differentiated with far reaching projections [...]

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GPR6 teaches B.F. Skinner that actions have consequences

Posted in G-protein, GPR6, Striatum, tagged , , , , , , , , on November 24, 2007 | Leave a Comment »

Image via Wikipedia I’m not sure what Skinner would have thought, but its clear that, nowadays, mechanisms of behavior can be understood in terms of dynamic changes in neural systems and, furthermore, that individual differences in these neural dynamics are heavily regulated by genetic variation. Consider the recent paper by Lobo et al., “Genetic control [...]

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