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Posts Tagged ‘Personalized medicine’

Personal freedom of genome access vs. innovation-crushing government regulation

Posted in Uncategorized, tagged , , on July 23, 2010 | Leave a Comment »

Image via Wikipedia Pointer to Daniel MacArthur’s (Genomes Unzipped) post on the recent political grandstanding in consumer genetics. This blog is more genomes, brains, social entrepreneurship and health 2.0 – than politics.   Hopefully the political phase will soon pass and some sensible regulations will preserve the right of consumers to access their genomes, while protecting [...]

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echoblog: Dad, Mom ‘n kids go all-in for full sequence

Posted in Uncategorized, tagged , , , , on April 22, 2010 | Leave a Comment »

Image via Wikipedia just a pointer to: Genetic Future’s pointer to the recent article, “Family become first to have DNA sequenced for non-medical reasons“.    The father suggests, “it will be ethically improper if you don’t have your children sequenced“. Early days.

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Genes in the brain are like genes in muscles

Posted in Basal Ganglia, Caudate nucleus, DAT, Dopamine, Putamen, Substantia nigra, Subthalamic nucleus, tagged , , , , , , , , , , , , , , , , on March 5, 2010 | 1 Comment »

Image by theloushe via Flickr ** PODCAST accompanies this post** I have a little boy who loves to run and jump and scream and shout – a lot.  And by this, I mean running – at full speed and smashing his head into my gut,  jumping – off the couch onto my head,  screaming – [...]

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Genetic road signs for super-size coffee SUV drivers

Posted in ADORA2A, DRD2, Uncategorized, tagged , , , , , , , , , , , , , , , , , on March 4, 2010 | Leave a Comment »

If you’re a coffee drinker, you may have noticed the new super-sized portions available at Starbucks.  On this note, it may be worth noting that caffeine is a potent psychoactive substance of which – too much – can turn your buzz into a full-blown panic disorder.  The Diagnostic and Statistical Manual for psychiatry outlines a [...]

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SLC1A1 SNPs as tiny deliveries on payment of big promise

Posted in SLC1A1, tagged , , , , , , , , , , , , , , , on December 15, 2009 | Leave a Comment »

Image via Wikipedia In their forecast “The World in 2010” special issue, the Economist points to “The looming crisis in human genetics” wherein scientists will reluctantly acknowledge that, even with super-cheap genome sequencing tools, we may not soon understand how genetic variation contributes to complex illness.  The argument is a valid one to be sure, [...]

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Indulging my inner rat over a few drinks

Posted in ADH1C, Amygdala, CDH13, Caudate nucleus, GATA4, Striatum, tagged , , , , , , , , , , , , , on November 16, 2009 | Leave a Comment »

Image by Scrunchleface via Flickr A recent GWAS study identified the 3′ region of the liver- (not brain) expressed PECR gene (rs7590720(G) and rs1344694(T)) on chromosome 2 as a risk factor for alcohol dependency.  These results, as reported by Treutlein et al., in “Genome-wide Association Study of Alcohol Dependence” were based on a population of [...]

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NIH Director lets his hair down on Colbert

Posted in Uncategorized, tagged , , , , , , on October 5, 2009 | Leave a Comment »

Image via Wikipedia Science IS fun … props to Francis Collins for going out on a limb for the younger crowd on the Colbert Report.

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echoblog: Buzz on direct-to-consumer genetic (hype) testing

Posted in Uncategorized, tagged , on September 2, 2009 | Leave a Comment »

Image via Wikipedia pointers to: “Personalized Genetics: DTC Genetic Tests Are Hype” and “The World of Genetic Genealogy and DTC Genetic Testing Never Sleeps…“ Even though the data collection technology still outpaces the deeper understanding of the data, we’re learning more and more all the time.

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Webcast to NIH conference on family history information

Posted in Uncategorized, tagged , , on August 21, 2009 | Leave a Comment »

pointer to next week’s conference in Bethesda NIH State-of-the-Science Conference: Family History and Improving Health.  From the website, “Family history is also critical to determining who will benefit from genetic testing for both common and rare conditions, and can facilitate interpretation of genetic test results.”  You can watch live or later via an archived webcast!

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Coriell personalized genome data starts to flow

Posted in Uncategorized, tagged , on August 13, 2009 | Leave a Comment »

Image via Wikipedia Last summer I took a day to drive to Camden, NJ to attend a free lecture & spit event at the Coriell Institute.  Today, I was pleased to find that the data are flowing through their user-friendly web portal.  After about 40 minutes of standardized online family, lifestyle & medical history questionnaires, [...]

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echoblog: Freakonomics hosts Anne Wojcicki

Posted in Uncategorized, tagged , , on August 12, 2009 | Leave a Comment »

Image via CrunchBase pointer to: Great Q&A on Freakonomics with 23andMe founder Anne Wojcicki. Nice overview of peoples’ concerns and interests in personal genomes.

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Resting state networks interact with APOE genotype to reveal risk decades before Alzheimer’s degeneration

Posted in APOE, Frontal cortex, Hippocampus, Middle temporal gyrus, tagged , , , , , , , , , , on August 4, 2009 | Leave a Comment »

Image via Wikipedia Few genes have been studies as intensely as apolipoprotein E (APOE).  In particular, one of its variants, the epsilon-4 allele has been especially scrutinized because it is correlated with an earlier onset (about 10 years earlier than average) of Alzheimer’s Disease.  Among the many roles of APOE – its just a tiny [...]

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“Imagene” that, Canadian system takes the lead in biomarker-driven mental health

Posted in Uncategorized, tagged , , on July 18, 2009 | Leave a Comment »

Image by Getty Images via Daylife While often the object of scorn from its capitalistic southern neighbor, the Canada Foundation for Innovation has just awarded Dr. David Kennedy a large research grant to deploy both neuroimaging and genetic markers in the development of personalised treatment for schizophrenia – through a program dubbed “neuroIMAGENE“.  Dr. Kennedy [...]

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GE’s personalized medicine effort flushed under economic duress

Posted in Uncategorized, tagged , on July 18, 2009 | Leave a Comment »

Image by TW Collins via Flickr Was bummed to hear Nick Haymenn say (download & listen to minute 10 on this Bloomberg News podcast) that GE healthcare has abandoned its molecular & imaging diagnostics program aimed at early detection and intervention. Crap, that sets things back quite a bit across the medical universe I suspect.

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Steven Pinker discusses the rise of personal genomics

Posted in Uncategorized, tagged , on January 10, 2009 | Leave a Comment »

Image by greeley via Flickr A great article (here in the NYTimes magazine) on one psychologist’s reaction to his genome and the new consumer genomics.

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Cytogenetic arrays to the clinic – stat !

Posted in Chromosome structural variants, tagged , , , on August 27, 2008 | Leave a Comment »

Image via Wikipedia Doctor David Ledbetter gives an eloquent editorial overview in his piece, “Cytogenetic Technology: Genotype and Phenotype” [doi: 10.1056/NEJMe0806570] on the renaissance underway in the field of medical cytogenetics. The use of high density arrays for genome-wide copy number variation has identified a slew of new sites showing recurrent microdeletion that are reliably [...]

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Another medical chumby … cool

Posted in Uncategorized, tagged , on July 25, 2008 | Leave a Comment »

Just saw this on engadget … fun and useful – just like chumby but with a medical twist. Who knows, it may someday make housecalls (see link below).Related articles by Zemanta Hacker goes bananas, creates robotic Chumby driving machine

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Intel’s new device – a step towards personalized medicine / health2.0

Posted in Uncategorized, tagged on April 20, 2008 | Leave a Comment »

Image via CrunchBase, source unknown Just re-posting from Gizmodo … this looks like a positive step … a medical chumby.

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Genetic ski patrol up and down the inverted U

Posted in DRD2, Dopamine, Frontal cortex, Striatum, tagged , on March 14, 2008 | Leave a Comment »

The selection and dosing of medication in psychiatry is far from scientific – even though a great deal of hard science goes into the preclinical design and clinical development. One reason, among many, has to do with the so-called ‘inverted-U-shaped’ relationship between the dose of a psychoactive compound and an individuals’ performance. Some folks show [...]

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Relief of big pharma’s antidepressant blues is as easy as ABC ?

Posted in ABCB1, tagged , , , on February 14, 2008 | Leave a Comment »

Image via Wikipedia Recent meta-analytical research, “Selective Publication of Antidepressant Trials and Its Influence on Apparent Efficacy” (N Engl J Med 2008;358:252-60) reveals that while 94% of published antidepressant drug trials show positive findings, only 51% of all such (published and unpublished) trials show positive effects (with a range of effect sizes from 11-69%). This [...]

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