Archive for the ‘VEGF’ Category

Vascular endothelial growth factor AImage via Wikipedia The mitogenic activities of the vascular endothelial growth factor protein family are well researched. A number of findings have linked this gene to learning and memory and hippocampal-dependent response to antidepressant medication. Indeed, its reasonable to expect that a mitogen such as VEGF would regulate hippocampal cell division and the accompanying benefits of new brain cells. Using high resolution structural MRI, Blumberg and team report evidence for such in their paper, “Influence of Vascular Endothelial Growth Factor Variation on Human Hippocampus Morphology“. Individuals with the CC genotype at rs833070 and rs2146323 – located in the intron of the VEGF-A gene displayed smaller hippocampal volumes than T-allele and A-allele carriers, respectively. These 2 snps lie in a haplotype block with rs833068 which was assayed in my 23andMe profile – indicating that I happen to carry the TT genotype at rs833070 giving me slightly larger, more neurogenic & resilient hippocampus – I suppose. Now, if I could just figure out a way to put it to good use !

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