“A man needs a name” and that man is Riccardo Sabatini. Serious games of -omes happening at Human Longevity.
Her: Why haven’t you asked me to try that one thing that you really want to try, but haven’t tried yet?
Him: It’s not something you can just “do” Honey. It takes time to learn. You know how I always overestimate how difficult it will be to learn something new? and then my prefrontal cortex – hippocampal connections go and mediate a rapid-fire one shot kind of learning?
Her: Awwww, don’t be embarrassed Dear. I am glad you are an ZNF804A rs1344706 heterozygote. If I had to choose between too quickly or going on and on for hours … well, let’s just say, my favorite part is always the hugging afterwards. Mmmmkay?
Don’t worry about your general cognitive ability genes. Otherwise, check out this study led by Drs. Joe Trampush and Anil Malhotra from the Feinstein Institute showing that the less frequent and non-ancestral (A) alelle of rs1906252 was associated with higher Spearman’s General Intelligence (g-factor) scores. This SNP sits 700 kilobases upstream of a putative ubiquitin ligase subunit (FBXL4) connected to severe psychomotor retardation. Loss-of-function in other ubiquitin ligase subunits have also been implicated in mental retardation.
A genetic predisposition to develop a drinking problem when exposed to beer is not, however, that reason.
However, with the exception of the large effects contributed by variation at ADH1B and ALDH2 in Asian populations (Edenberg 2007; Hurley and Edenberg 2012), there is little consistency across studies. Nevertheless, one gene encoding cadherin 13 (CDH13) was replicated in four independent studies among all SNPs that were significant at a nominal P value (Johnson et al. 2006; Liu et al. 2006b; Treutlein et al. 2009; Lind et al. 2010).
If you’re going to make a clone army, you might want to avoid the CDH13 rs11640875 A alleles. Also keep in mind that there are some 100 different types of cadherin molecules expressed in the brain and they mediate all manner of cell-to-cell contact and signalling processes. Not surprisingly, this class of cell adhesion molecules are widely associated with mental disorders.
It’s summer people. We live in the genome age. Check your rs309375 genotype.
They say information wants to be free, but maybe it’s more that people want to be free and crave information that helps them acquire freedom. So maybe there is a simple test to apply to any subsequent blog posts here.
Does this post contain information that might help someone on their quest toward personal freedom or self-determination?