Just so you know, neither of you are in charge … so please stop acting like hyper oxygen sensitive drama queens with self-absorbed Lewy body issues when it’s not even really about either of you. I realize that you both have to work in a toxic stew of lethal reactive oxygen species to pump out limitless quantities of ATP and then die in a shallow, unmarked DNA repair enzyme complex … all so I can lay around and watch The Jerry Springer Show. I get it. You are under appreciated. Listen, if you two would stop sniping at each other on Facebook, I promise I’ll eat more kale, volunteer at a soup kitchen and go to yoga 3 times a week. Besides, AMP Kinase says that if you don’t get your shit together, he’s going to send mTORC1 over and teach both of you what being “mTORC1-dependent” is all about.
Posts Tagged ‘Reactive oxygen species’
Dear nuclear and mitochondrial genomes
Posted in Mitochondria, Uncategorized, tagged Mitochondrion, neurodegeneration, Reactive oxygen species on November 21, 2012| Leave a Comment »
The heart sees the loss of that fantastic yoga bod
Posted in aging, Buddhism, tagged aging, Art, Buddism, Reactive oxygen species on October 7, 2010| 1 Comment »
Last night I was watching a TV show on the story of The Buddha. There was a part in the story where, “Siddhartha saw a man lying on the ground and moaning. Out of compassion, he rushed over to the man. Channa warned him that the man was sick and that everyone, even noble people like Siddhartha or the king could get sick.” Later, “Siddhartha lost all interest in watching the dancing girls and other such pleasures. He kept on thinking instead about how to free himself and others from sickness, ageing and death.”
When Siddhartha looked at the beautiful young dancers, he saw them as old, dying women and felt empathy for the suffering they would endure in their lives.
This part of the story reminded me of the way mass marketeers often use sexuality to market yoga, and the backlash it creates. I thought that this moment in Siddhartha’s life really captured the “true” spirit of yoga/Buddhism – in stark contrast to so many slick, sexy advertisements. Yoga and meditation – while enjoyed by many young and beautiful people – provides something deeper – a path to cope with the painful, frightening and inexorable loss one’s health, (outer) beauty, memory and breath.
I’d be a hypocrite to say I’m averse to the “sex sells” media, but Siddhartha’s insight is one to keep in mind – and heart.
Science and the possibility of living (almost) forever
Posted in aging, artist, longevity, tagged aging, Immortality, longevity, Physical body, Reactive oxygen species, religion, soul on July 16, 2010| Leave a Comment »
- Image via Wikipedia
The concept of “immortality” lies deep in the core of Indian spirituality and the religious traditions of many other cultures. Its probably not a coincidence that one of the first and, still, most influential books on the history of yoga is entitled, Yoga: Immortality and Freedom by Mircea Eliade (you can read the book online here)
Most of the time, this refers to some part of a person – the soul, spirit or otherwise – that lives on forever after the physical body decays. That we are able to recognize and ponder our mortality and the suffering of the physical body, is an integral part of why, in the first place, we seek to practice religion (covered here).
I mean, no one ever took the concept of immortality LITERALLY, did they? Perhaps not. Until now. Check out the trailer for a new movie that opens tonight in New York City on the science of Aging: To Age or Not To Age – a film by Robert Kane Pappas. At the center of this film is likely the so-called longevity gene known as SIRT1 (covered earlier here).
rs4880 knows that when I’m breathing I’m dying
Posted in SOD2, tagged aging, Brain, Mental health, Mitochondrion, Neuron, Oxygen, Reactive oxygen species, Superoxide, Superoxide dismutase on February 19, 2010| Leave a Comment »
- Image by MAMJODH via Flickr
Oxygen is the key to life. This is because it loves electrons. In the mitochondria of every cell in your body, oxygen (in is atmospheric O2 state) serves as the ultimate electron acceptor and provides the chemical energy that drives the formation of ATP (a form of chemical energy storage that our body uses for all its cellular functions).
Oxygen is the key to death. This is because it loves electrons. When so-called reactive oxygen species (small molecules that contain oxygen in an ionized form) are permitted to roam free in cell and the body, they can indiscriminately pull electrons from other molecules (oxidation) and cause undesirable protein damage and premature cell death.
There is no escaping this chemical reality. The very substance that giveth life, doth take it away and our longevity teeters on the quantum mechanical balance of electrons whizzing around the nucleus of the oxygen atom. (I’ll think about this and the chemical symbol for oxygen (O), next time I chant “Om” in yoga class).
So it is with this humbling knowledge that many search for ways to optimize this balance (several populations have already figured out how to routinely live to 100+ years!) or at least improve the quality of our naturally limited life-span. Light exercise, vegetables, friends and not too much alcohol.
Consider the recent paper, by Srivastava et al., “Association of SOD2, a Mitochondrial Antioxidant Enzyme, with Gray Matter Volume Shrinkage in Alcoholics” [doi: 10.1038/npp.2009.217]. The authors report that shrinkage of the neocortex (gray matter) of the brain is associated chronic high levels of alcohol consumption. That’s right, too much alcohol shrinks your brain. Yikes! How does alcohol exert its effect on brain shrinkage? Well, the authors measured many aspects of liver function (various enzyme levels), but these did not correlate with gray matter shrinkage. Rather, the authors traced the effect to an enzyme that normally keeps harmful reactive oxygen species at bay – the so-called superoxide dismutase (SOD) enzyme. We all have this enzyme, but in some of us, those who carry the rs4880 “G” allele of our SOD2 gene produce an enzyme that has an alanine at position 16 (Ala16) and is less active than the rs4880 “A” allele which encodes a more active enzyme with a Valine at position 16 (Val16). The authors report that the rs10370 “TT”, rs4880 “GG” diplo-genotype (diplotype) was associated with more gray matter shrinkage in 76 individuals who report chronic high levels of alcohol consumption. Here, the less active form of SOD2 is seemingly less able to metabolize all the harmful superoxide radicals that are generated during chronic exposure to alcohol. Apparently their neurons are in retreat.