Genes 2 Brains 2 Mind 2 Me

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Thanks so very much to the folks at SNPedia for developing and sharing the Promethease analysis tool. What a delight to delve into my 23andMe profile ! I stumbled onto the usual dreary risks for this and that, and yes, I know I’m at risk for baldness, but did come up with a few bonus IQ points and moreover an allele that protects me from cannabis dependence (will have to return to Nijmegen sooner than later I suppose).

Just a sampling from the report … what’s in YOUR genome ?

rs2165241(T;T)  >10x increased risk of exfoliation glaucoma (LOXL1)
rs2180439(T;T)  2x increased risk of baldness
rs1136287(T;T)  3.9x increased risk of wet age related macular degeneration (PEDF)
rs1426654(A;A)  probably light-skinned, European ancestry
rs601338(A;A)  resistance to Norwalk virus infection
rs324650(A;T)  somewhat higher IQ (CHRM2)
rs1815739(C;T)  mix of sprinting & endurance muscles (ACTN3)
rs16891982(C;G)  if European, 7x more likely to have black hair (SLC45A2)
rs806368(C;C)  lower risk of the development of substance dependence
rs1954787(T;T)  ~10% less likely to respond to citalopram (HTR2A)
rs17822931(C;T)  wet earwax
rs237025(A;A)  MET/MET increased diabetes susceptibility
rs6449213(T;T)  ~4x higher risk for hyperuracemia
rs1015362(C;C)  2-4x higher risk of sun sensitivity if part of risk haplotype (ASIP)
rs1800497(G;G)  A2/A2 bupropion effective (DRD2)
rs363039(A;G)  2+ IQ points (SNAP25)
rs2383207(A;G)  increased risk for heart disease
rs2987983(G;G)  increased risk for prostate cancer
rs1800955(C;C)  increased susceptibility to novelty seeking (DRD4)
rs2279744(G;G)  generally more cancer prone (MDM2)
rs10260404(C;C) rs10239794(C;C) haplotype strongly associated with ALS
rs283413(A;C)  3.2x higher risk for PD (ADH1C)
rs1024611(G;G)  increased risk of exercise induced ischemia (CCL2)
rs1328674(T;T)  higher risk for RA (HTR2A)
rs2107301(A;A)  2.47x higher risk for prostate cancer
rs1801270(A;C)  increased risk for lung cancer
rs1571801(T;T)  >1.36x risk for prostate cancer
rs1799724(C;T)  weak risk for Alzheimer’s Disease
rs733618(C;T)  1.87x risk for myasthenia gravis (CTLA4)
rs7480010(G;G)  increased susceptibility to Type II Diabetes
rs3018362(A;A)  increases susceptibility to Osteoporotic fractures
rs4870044(T;T)  increases susceptibility to Bone mineral density variations
rs806380(G;G)  protection from cannabis dependence
rs17696736(G;G)  associated with type-1 diabetes