Some call it “phantom heritability” while others call it “dark matter” … whatever … genes are definitely not “beans in a bag” that independently add up to influence development. They interact in complex bio-physical-3D-proteo-ribonucleic-tertiary-etc.-etc. ways.
“Ultimately,” they concluded, “the most important goal for biomedical research is not explaining heritability — that is, predicting personalized patient risk — but understanding pathways underlying disease and using that knowledge to develop strategies for therapy and prevention.” [paper]
Note to self: Abandon any musings of future employment in the “predicting personalized patient risk” business … unless someone comes up with a useful model that helps best fit these interactions.
Genes 2 Brains 2 Mind 2 Me 
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