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Posts Tagged ‘endophenotype’

Probably not.  But, just in case you were wondering, it looks a lot like this.  Its (um, YOU) are a multi-level model showing overlap in genetic targets as well as signaling and neural systems between disparate latent constructs of memory and intelligence with no less than five levels of phenotype complexity (gene, signaling, neural, cognitive, and syndrome).  This super-techno-geeky-view of humanity is because:

In order to identify phenotype constructs that may ultimately be successful in genetic association studies, the field needs to move beyond the now traditional endophenotype approach and begin to build and refine multivariate multilevel phenotype models.

Check out the paper here and the super-cool PubMed exploration tools … especially PubAtlas.

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