Posts Tagged ‘Functional neuroimaging’

Dr. Tal Yarkoni: “Functional MRI in Health Psychology and beyond: A call for caution

In practice, the modal fMRI sample size of 15 – 20 subjects often provides little power to detect anything but very large effects (Yarkoni, 2009). For example, a one-sample t test performed on 20 subjects at a statistical threshold of p < .001 (the modal threshold in the fMRI literature) has only 40% power to detect even a canonically ‘large’ effect of d = 0.8. For a correlational analysis, the same sample size provides only 12% power to detect an extremely large correlation of r = 0.5.

How many LOW and UNDER-powered imaging genetic studies (where genetic variation is merely one of many variables correlated with individual differences in task or baseline BOLD responses) have I have covered in this blog?  Eeeek!  I’d better not go there … I’ll go to ENIGMA instead.

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Just playing around with Joe D‘s new PubMed analysis tools – Thanks Joe ! My own area of research involves linking genetic data to functional neuroimaging data to begin to understand how genetic variation influences neural network dynamics and cognitive development in general. The term “imaging-genetics” was initially used for this purpose at the first Imaging-Genetics conference in 2005 and since then. I like the figure generated by Joe’s term trending tool since it shows the early blips of activity in this nascent field.

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