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Posts Tagged ‘Meta-analysis’

The publication of positive genetic association results is always something to cheer about although most of us know that on a different day, with a different sample, the results could just as easily been flat. So when a meta-analytical paper appears that actually supports a previous finding, you have to savor the sweet joy of it. So it is that Marcus Munafo and colleagues under the leadership of Jonathan Flint – one of the best meta-analytical assessors in the biz – report that the “C” allele of rs1800955 in the dopamine d4 receptor (DRD4) gene (doi: 10.1016/j.biopsych.2007.04.006) survives an analysis of several dozen studies on genetics and personality. Although small, “The evidence from our final meta-analysis indicatest hat the true effect size of the C-521T polymorphism on novelty seeking and impulsivity traits, if genuine, may account for up to 3%o of phenotypic variance.” I, perhaps due to my “C” allele am excited !

MUNAFO, M. (2008). Association of the Dopamine D4 Receptor (DRD4) Gene and Approach-Related Personality Traits: Meta-Analysis and New Data. Biological Psychiatry, 63(2), 197-206. DOI: 10.1016/j.biopsych.2007.04.006

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