It’s summer people. We live in the genome age. Check your rs309375 genotype.

Information and freedom

They say information wants to be free, but maybe it’s more that people want to be free and crave information that helps them acquire freedom. So maybe there is a simple test to apply to any subsequent blog posts here.

Does this post contain information that might help someone on their quest toward personal freedom or self-determination?


The  genetics of economics and economics of genetics are really freaky topics.

On the one hand, we spend most of our lives making economic decisions … how to spend time? money? affection? You know, “He’s cute, but has a lame job” and, “I feel like I’m getting a better deal at Five Guys because they give away the peanuts for free.” Genetic research seems to be “worth it” because variation in genetic data might underpin variation in economic behavior (particularly in the healthcare marketplace).

On the other hand, genetic data seems to have little or no economic face value. I mean, they are practically giving the data away at $100 for your SNP-ome and $1,000 for your full genome.

So it seems that consumers are now part of an experiment where they may freely access their personal genetic information and try to figure out how to use it in some sort of economically advantageous way. Meanwhile scientists can (with consent) meta-analytically track the genotypes of these consumers and discover what genotypes are associated with good economic decisions. It’s freaky. It’s fascinating. It’s big data. Whatever.

The downside to “consumer as guinea pig” is that the free marketplace is full of liars and exploiters, and will soon be awash in every sort of hokey “geno-” this and “geno-” and “g’s” fused with all sorts of words that begin with “en”. I mean, have you ever not been paralyzed in the salad dressing aisle? Do we really need “specially formulated for rs1234567 AA” geno-dressings?

Which is why I really think anyone who describes himself as a genoeconomist and founder of a gentrepreneurship consortium, really needs to take it down a couple of notches. This type of self-branding is what the liars and exploiters do.

Hundreds of millions of people are desperately looking for work. The liars and exploiters have wrecked the global economy for decades to come. People are suffering. The publication of meta-analytic studies that show that self-employment, while somewhat heritable, is a complex polygenic trait (um, no shit) feels to me like an insensitive slap in the face to people who are unemployed through no fault of their own.

Rant over.


American Omic


… except for the genes that allow us to totally reset our expectations about social rejection.

Thank you Jia Jiang for helping me to take everything I had learned about the psychology, neurobiology and genetics of social rejection and rejection sensitivity … and throw it in the garbage.

Apparently the best part of having a human brain is that we have the biological predisposition to transcend our own biological predispositions.


The “T” allele of rs1378810 in your DNAJC13 gene has been associated with a slight benefit (less than 0.4% variance) in general cognitive ability. You can check your 23andMe profile.*  What? You’re a TT? Ooooh … nobody is impressed. But let’s not make light of our DNAJ genes just yet.

Consider the critical role of DNAJC5, a so-called cysteine-string protein (because it encodes a protein with an array of cysteine residues). This protein helps synaptic vesicles fuse and un-fuse so that your neurons can release and re-cycle tiny packets of neurotransmitters – which is how neurons send signals to one another. Yeah, vesicle fusion is really important … and is happening like a quadriillion times right now in your brain.

Mutations in the cysteine string of DNAJC5 have been associated with Huntington’s disease.

[artwork credit]

*Interpreting 23andMe data here can be confusing because 23andMe lists an A or T as possible alleles but one isn’t always sure which strand the research literature refers to and if that strand is the same strand that 23andMe is reading from. Luckily SNPedia points out that an rs1378810 TT is in tight linkage disequilibrium with rs2133692 TT (T or C alleles) so you can check this genotype on 23andMe to infer your rs1378810 genotype. My 23andMe profile says AA at rs1378810 and TT at rs2133692, so I think I have the slightly beneficial TT genotype … but I’m really not sure. Confused? Me too. But like the research suggests, this genotype really doesn’t add much to one’s general cognitive ability.


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